The clock ⏰ is ticking when it comes to lack of perfusion. How fast? On average in a large vessel ischemic CVA, 32,000 neurons are lost causing an age acceleration of 8.7 hours, every second! So, in the average stroke, 1.2 billion neurons are lost causing an age acceleration of 37 years! Time is tissue, and time is NOT on our side! How fast you assess, get vitals, and generally get information, comes into play with the extent of damage to your patient's brain.